[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methanol
نویسندگان
چکیده
The title compound, C(19)H(16)FNO, crystallizes with two independent mol-ecules in the asymmetric unit. In the two mol-ecules, the dihedral angles between the benzene and quinoline rings are 72.6 (5) and 76.2 (5)°, between the cyclo-propane and quinoline rings they are 65.2 (5) and 66.0 (5)°, and between the benzene and cyclo-propane rings they are 25.9 (5) and 33.9 (5)°. There are inter-molecular O-H⋯O, O-H⋯N and C-H⋯O hydrogen bonds, as well as intra-molecular C-H⋯O hydrogen bonds, which may be effective in stabilizing the crystal structure.
منابع مشابه
Design, synthesis and potential anti-proliferative activity of some novel 4-aminoquinoline derivatives.
Novel nineteen compounds based on a 4-aminoquinoline scaffold were designed and synthesized as potential antiproliferative agents. The new compounds were N-substituted at the 4-position by aryl or heteroaryl (1-9), quinolin- 3-yl (10), 2-methylquinolin-3-yl (11), thiazol-2-yl (12), and dapsone moieties (13, 14 and 18). Bis-compounds 15, 16 and 19 were also synthesized to assess their biological...
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